• Research

    In vitro bone mechanobiology

    In the area of in vitro mechanobiology of osteocytes, osteoblasts and osteoclasts, we have developed both two-dimensional (2D) and three-dimensional (3D) models for testing a series of novel hypotheses regarding the role of the osteocyte network in sensing mechanical signals and regulating osteoblast or osteoclast functions...
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  • Research

    Quasi-3D cell mechanics

    We have recently developed a novel quasi-3D microscopy system for the study of cells under fluid flow. This novel technology provides an amazing ability to simultaneously visualize and quantify, in real-time and in 3D, the dynamics of two cytoskeletal components and signal activation via fluorescence resonance energy transfer (FRET)...
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  • Research

    ITS and FEA of Skeletons

    In the area of image based microstructural and finite element analyses of human skeletons, we have innovated and advanced an individual trabeculae segmentation (ITS) technique and demonstrated its unique power in basic micromechanics of human trabecular bone...
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Latest from BBL

We have two exciting new publications from the clinical mechanics group and the mechanobiology group in the BBL!
Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis
Yan Chen, Yizhong Hu, Y Eric Yu, Xingjian Zhang, Tezita Watts, Bin Zhou, Ji Wang, Ting Wang, Weiwei Zhao, Kwong Yuen Chiu, Frankie KL Leung, Xu Cao, William Macaulay, Kyle K Nishiyama, Elizabeth Shane, William W Lu, and X Edward Guo
Journal of Bone and Mineral Research, Vol. 33, No. 2, February 2018, pp 316–327

Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation
Andrea E. Morrell, Genevieve N. Brown, Samuel T. Robinson, Rachel L. Sattler, Andrew D. Baik, Gehua Zhen, Xu Cao, Lynda F. Bonewald, Weiyang Jin, Lance C. Kam & X. Edward Guo
Bone Research Volume 6, Article number: 6 (2018)

  • The Bone Bioengineering Lab is currently seeking Ph.D. applicants with an engineering background and experience/interest in cell biology, in vitro work, or cell signaling to begin in Fall 2019. Please contact Dr. Guo (exg1@columbia.edu) with your CV.

  • The Bone Bionengineering lab has recently joined Twitter! Follow us @ColumbiaBBL for live updates from conferences, recent publications, and other lab news.

  • A listing of all publications produced by the Bone Bioengineering Laboratory.

  • Learn more about the people that work at the Bone Bioengineering Laboratory.

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