• Research

    In vitro bone mechanobiology

    In the area of in vitro mechanobiology of osteocytes, osteoblasts and osteoclasts, we have developed both two-dimensional (2D) and three-dimensional (3D) models for testing a series of novel hypotheses regarding the role of the osteocyte network in sensing mechanical signals and regulating osteoblast or osteoclast functions...
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  • Research

    Quasi-3D cell mechanics

    We have recently developed a novel quasi-3D microscopy system for the study of cells under fluid flow. This novel technology provides an amazing ability to simultaneously visualize and quantify, in real-time and in 3D, the dynamics of two cytoskeletal components and signal activation via fluorescence resonance energy transfer (FRET)...
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  • Research

    ITS and FEA of Skeletons

    In the area of image based microstructural and finite element analyses of human skeletons, we have innovated and advanced an individual trabeculae segmentation (ITS) technique and demonstrated its unique power in basic micromechanics of human trabecular bone...
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Research Areas

The Bone Bioengineering Laboratory performs multiscale research in two main areas: clinical mechanics and mechanobiology. The BBL has also developed cutting edge software called Individual Trabeculae Segmentation (ITS) , which is used in both our work and others for rapid and novel analysis of trabecular bone parameters.

The clinical mechanics group studies the affect of both morphology and mechanical properties of individual trabeculae on whole bone properties. This is accomplished through use of cutting-edge imaging technologies and advanced software to study microstructural changes in bone as well as customized mechanical loading devices that allow mechanical properties to be derived at multiple scales.

The mechanobiology group studies the mechanisms of osteocyte mechanosensation and mechanotransduction. We have developed novel in vitro, ex vivo, and in vivo technologies that allow the study of osteocyte mechanobiology at several scales - from the immediate response of single cells to mechanical stimulus all the way through effects on long-term, whole bone response to loading when osteocyte function is impaired.

Visit each area's respective page to read a high-level description and learn about specific projects in that area.

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