BBL Director


Xiang-Dong Edward Guo, B.S., M.S., Ph.D.
Professor of Biomedical Engineering


Field of Specialization

Biomechanics: Bone Mechanics, Imaging Analysis of Bone Microstructure, Biomechanics of Bone Cells, Micropatterning of Cells, Mechanobiology of Bone

Academic Training

Colleges and Universities Attended

1980-1984
Undergraduate Study in Applied Mechanics
Department of Mechanics, Peking University, Beijing, P. R. China
B.S. in Applied Mechanics

Bachelor Thesis: Diffusion of Macromolecules Across the Arterial Wall in the
Presence of Multiple Endothelial Injuries, Sponsor: Professor Gong-Bi Wen

Published: Guo, X. and Wen, G-B (1985) Diffusion of macromolecules Across the Arterial Wall in the Presence of Multiple Endothelial Injuries, Proceedings of the 1st National Youth Biomedical Engineering Conference of China (received Class Award), Anhui, P. R. China.

1984-1988
Doctoral Graduate Study in Biomechanics
Department of Mechanics, Peking University, Beijing, P. R. China

1988-1989
Doctoral Graduate Study in Mechanical Engineering
Department of Mechanical Engineering, The City College of the City University of New York, New York, New York

1989-1990
Graduate Study in Engineering Science
Division of Applied Sciences, Harvard University, Cambridge, Massachusetts
M.S. in Engineering Sciences

1990-1994
Doctoral Graduate Study in Medical Engineering and Medical Physics
Harvard-MIT Division of Health Science and Technology
Division of Applied Sciences, Harvard University, Cambridge, Massachusetts
Ph.D. in Medical Engineering and Medical Physics (Harvard University)

Ph.D. Thesis: Fatigue of Trabecular Bone, Sponsors: Professors Thomas A. McMahon, Wilson C. Hayes, and Lorna J. Gibson

Published: Michel, M. C., Guo, X.-D., Gibson, L. J., McMahon, T. A. and Hayes, W. C. (1993) Compressive Fatigue Behavior of Bovine Trabecular Bone, J. Biomechanics, 26, p453-463.
Guo, X. E., Gibson, L. J., McMahon, T. A., Keaveny, T. M. and Hayes, W. C. (1994) Finite Element Modeling of Damage Accumulation in Trabecular Bone Under Cyclic Loading, J. Biomechanics, 27, p145-155.
Keaveny, T. M., Guo, X. E., Watchtel, E. F., McMahon, T. A. and Hayes, W. C. (1994) Trabecular Bone Exhibits Fully Linear Elastic Behavior and Yields at Low Strains, J. Biomechanics, 27(9): 1127-1136.
Keaveny, T. M., Watchtel, E. F., Guo, X. E., and Hayes, W. C. (1994) The Mechanical Properties of Damaged Trabecular Bone, J. Biomechanics, 27(9): 1309-1318.Bowman, S. M., Guo, X. E., Cheng, D. W., Keaveny, T. M., Gibson, L. J., Hayes, W. C. and McMahon, T. A. (1998) Creep Contributes to the Fatigue Behavior of Bovine Trabecular Bone, J. Biomech. Eng., 120, p647-654.
Bowman, S. M., Guo, X. E., Cheng, D. W., Keaveny, T. M., Gibson, L. J., Hayes, W. C., and McMahon, T. A. (1998) Creep Contributes to the Fatigue Behavior of Bovine Trabecular Bone, J. Biomech. Eng., 120(5): 647-654.
Guo, X. E., and Gibson, L. J. (1999) Behavior of Intact and Damaged Honeycombs: A Finite Element Study, Intl. J. Mech. Eng., 41, p85-105.

1993-1996
Postdoctoral Research in Orthopaedic Bioengineering
Orthopaedic Research Laboratories, The University of Michigan, Ann Arbor, Michigan
Mentor: Professor Steven A. Goldstein

1997
Trainee of Summer Course in Physiology: Molecular Signal Transduction (funded by NIH training grant)
Marine Biology Laboratory, Woods Hole, Massachusetts

Employment Record and Professional Experience

1984-1988
Graduate Research Assistant, Department of Mechanics, Peking University, Beijing, P. R. China

1988-1989
Graduate Research Assistant, Department of Mechanical Engineering, The City College of the City University of New York

1990-1993
Graduate Research Assistant, Orthopaedic Biomechanics Laboratory, Harvard University Medical School

1993-1996
Postdoctoral Research Fellow, Orthopaedic Research Laboratories, University of Michigan

1996-1998
Assistant Professor of Mechanical Engineering, Department of Mechanical Engineering, Columbia University

1998-2001
Assistant Professor of Biomedical Engineering, Department of Biomedical Engineering, Columbia University

2001-2007
Associate Professor of Biomedical Engineering, (with tenure 2003) Department of Biomedical Engineering, Columbia University

2004-2007
Associate Professor of Dental and Craniofacial Bioengineering (in Dentistry), College of Dental Medicine, Columbia University

2007-present
Professor of Biomedical Engineering, Department of Biomedical Engineering, Columbia University

Research Appointments

1984-1988
Graduate Research Assistant, Department of Mechanics, Peking University

1988-1989
Graduate Research Assistant, Department of Mechanical Engineering, The City College of the City University of New York

1990-1993
Graduate Research Assistant, Orthopaedic Biomechanics Laboratory, Harvard University Medical School

1993-1996
Postdoctoral Research Fellow, Orthopaedic Research Laboratories, The University of Michigan

1996-2001
Associate in Orthopaedic Research, New York Orthopaedic Hospital Research Laboratory, New York-Presbyterian Hospital

1997-present
Director, Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University

2008
Adjunct Professor, School of Aeronautics and Astronautics, Xian Jiaotong University, Xian, P. R. China

Fellowships and Honors

1985
Class Award from the First National Youth Biomedical Engineering Conference of P. R. China.

1989
Graduate Fellowship, Division of Applied Sciences, Harvard University

1990
HST Graduate Fellowship, Harvard-MIT Division of Health Science and Technology

1992
The New Investigator Recognition Award, Orthopaedic Research Society

1994
Postdoctoral Trainee of National Institute on Aging

1995
National Research Service Award, National Institutes of Health

1997
Marine Biological Laboratory Summer Course Fellowship, Marine Biological Laboratory

1999
National Science Foundation CAREER Award

2006
Funds for Talented Professionals (Joint Research Fund for Overseas Chinese Young Scholars), National Natural Science Foundation of China

2006
Fellow, American Institute for Medical and Biological Engineering

Society and Membership

Member
American Society of Mechanical Engineers, since 1993

Member
American Society of Biomechanics, since 1993

Member
Orthopaedic Research Society, since 1995

Member
Sigma Xi Scientific Research Society since 1998

Member
American Association for the Advancement of Science, since 1998

Vice-Chair
Solid Mechanics Committee of Bioengineering Division of American Society of Mechanical Engineers, 2001

Track Chair
Orthopaedic Bioengineering Track, 2005 Annual Meeting of Biomedical Engineering Society

Member
US National Committee on Biomechanics since 2005

Member
Provisional Executive Committee, World Association of Chinese Biomedical Engineers

Track Chair
Cellular and Molecular Biomechanics, Orthopaedic Research Society 2005-2008

Member
World Council of Biomechanics, 2006-2018

Treasurer
World Association of Chinese Biomedical Engineers, 2007-2009

Member
Council, The Society for Physical Regulation in Biology and Medicine

President-Elect
International Chinese Hard Tissue Society 2009-2011

President
International Chinese Hard Tissue Society 2011-2013

Program Chair
The Society for Physical Regulation in Biology and Medicine, 2010-2011

Vice President
The Society for Physical Regulation in Biology and Medicine, 2011-2012

President
The Society for Physical Regulation in Biology and Medicine, 2012-2013

Member
Board of Directors, International Chinese Hard Tissue Society 2009-2011

Member
Program Committee of Orthopaedic Research Society, 2009-2010

Member
Membership Committee of Orthopaedic Research Society, 2010-2011

Vice Chair
Membership Committee of Orthopaedic Research Society, 2011-2012

Chair
Membership Committee of Orthopaedic Research Society, 2011-2012

Member
Board of Directors, Orthopaedic Research Society, 2012-2013

Review and Advisory Activities

Reviewer
Journal of Biomechanics, since 1994

Reviewer
ASME Journal of Biomechanical Engineering, since 1994

Reviewer
Journal of Orthopaedic Research, since 1996

Reviewer
Annals of Biomedical Engineering, since 1996

Reviewer
Bone, since 1996

Reviewer
Journal of Bone and Mineral Research, since 1997

Reviewer
International Journal of Structures and Solids, since 1997

Member
Board of Editors, Journal of Medical Biomechanics, since 2002

Editor-in-Chief
Molecular and Cellular Biomechanics, 2005-2007

Managing Editor
Frontier in Bioscience, since 2006

Editor-in-Chief
Cellular and Molecular Bioengineering, an official and international journal
Biomedical Engineering Society, since 2007

Associate Editor
Guest, Journal of Biomechanical Engineering, 2008-2009

Associate Editor
Journal of Biomechanical Engineering, 2009-

Associate Editor-in-Chief
Acta Mechanica Sinica, since 2008

Panelist
Biomedical Engineering and Research to Aid Persons with Disabilities, Research Grant Review Panel, March 1999

Ad Hoc Member
Special Emphasis Study Section, NIAMS of National Institutes of Health, October 2000

Panelist
Biomedical Engineering and Research to Aid Persons with Disabilities, CAREER Panel, January 2001

Member
Peer Review Panel of American Institute of Biological Sciences, USAMRMC Bone Health and Military Medical Readiness 2001, February, 2001

Panelist
NASA Center Grant Review, February 19-20, 2002

Ad Hoc Member
Orthopaedics Study Section, NIAMS of National Institutes of Health, March 2002

Site-Visitor
NASA Center Grant Site Visit Team, May 28-31, 2002

Panelist
Special Grant Review Committee, NIDCR of National Institutes of Health, June 19, 2003

Panelist
Special Panel for Program Project Grant, NIAMS of National Institutes of Health, October 2003

Panelist
Special Grant Review Committee, NIDCR of National Institutes of Health, June 17, 2004

Panelist
Special Emphasis Panel on MABS, National Institutes of Health, June 24, 2004

Ad Hoc Member
Skeletal Biology Structure and regeneration Study Section, NIAMS of National Institutes of Health, June 27-29, 2004

Panelist
Special Emphasis Panel, NIAMS of National Institutes of Health, December 14, 2004

Panelist
Special Emphasis Panel, NIAMS of National Institutes of Health, March 9, 2005

Panelist
Special Emphasis Panel, NIAMS of National Institutes of Health, April 8, 2005

Panelist
Special Emphasis Panel, NIAMS of National Institutes of Health, November 22, 2005

Standing Member
Skeletal Biology Structure and regeneration Study Section, NIAMS of National Institutes of Health since February 2005-2009.

Member
External Advisory Committee, Institute of Biomechanics and Medical Engineering, Tsinghua University, Beijing, China, since 2006

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