New BBL Publications

We have two exciting new publications from the clinical mechanics group and the mechanobiology group in the BBL!

Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis
Yan Chen, Yizhong Hu, Y Eric Yu, Xingjian Zhang, Tezita Watts, Bin Zhou, Ji Wang, Ting Wang, Weiwei Zhao, Kwong Yuen Chiu, Frankie KL Leung, Xu Cao, William Macaulay, Kyle K Nishiyama, Elizabeth Shane, William W Lu, and X Edward Guo
Journal of Bone and Mineral Research, Vol. 33, No. 2, February 2018, pp 316–327

Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation
Andrea E. Morrell, Genevieve N. Brown, Samuel T. Robinson, Rachel L. Sattler, Andrew D. Baik, Gehua Zhen, Xu Cao, Lynda F. Bonewald, Weiyang Jin, Lance C. Kam & X. Edward Guo
Bone Research Volume 6, Article number: 6 (2018)

Editorial Summary
How bone grows in response to loading
People gain bone in response to exercise and lose it during prolonged bedrest; now we’re closer to understanding how this happens.

Bone cells called osteocytes act as mechanical sensors, responding to changes in force by regulating the activity of bone-forming osteoblasts and bone- resorbing osteoclasts. X. Edward Guo at Columbia University in New York and colleagues had previously shown that osteocytes exhibit oscillations in intracellular calcium in response to mechanical stimulation, but the downstream effects of this had been unclear. Using multiple approaches, they have now shown that the cytoskeleton contracts in response to these oscillations, in turn triggering the production and release of extracellular vesicles containing bone-regulatory proteins.

When calcium signaling was blocked, vesicle production and release was blunted, and mice failed to show the normal increase in bone formation in response to mechanical loading. show less

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